Gambaran Netrofil Pada Pasien Covid-19 Di Rumah Sakit Siloam Bogor
DOI:
https://doi.org/10.37012/anakes.v7i2.695Abstract
SARS-CoV-2 adalah virus baru yang muncul pertama kali di Wuhan pada 31Desember 2019. Badan Kesehatan Dunia (WHO) memberi nama penyakit yang disebabkan virus tersebut, COVID-19. Virus ini menimbulkan wabah diberbagai negara termasuk Indonesia. Dilakukan pemeriksaan skrining untuk pasien COVID-19 salah satunya yaitu pemeriksaan kadar neutrofil pada darah. Neutrofil adalah sel darah putih pertama yang direkrut ke tempat peradangan akut. Tujuan dari penelitian ini yaitu mengetahui gambaran neutrofil pada pasien COVID-19. Penelitian ini dilakukan pada bulan Maret – Juni 2021 di RS Siloam Bogor pada pasien dengan diagnosa COVID-19.Penelitian diambil dari data sekunder sebanyak 113 data yang diolah dan disusun dalam bentuk tabel. Hasil penelitian yang berasal dari 113 data didapatkanhasil pasien wanita lebih tinggi daripada laki-laki, hasil neutrofil cenderung meningkat pada wanita dan laki-laki. Pasien didominasi oleh wanita usia 41-50 tahun. Didapatkan hasil pasien COVID-19 di RS Siloam Bogor BulanOktober - Desember 2020 paling banyak adalah perempuan dengan rentang usia41-50 tahun dengan penyakit penyerta yang mengalami peningkatan nilai neutrofil, dengan adanya penelitian ini diharapkan dapat memperluas pengetahuan mengenai pemeriksaan neutrofil pada pasien COVID-19.
Kata kunci         : Neutrofil, COVID-19, SARS-COV-2
References
Burhan, E., Dwi Susanto, A., Isbaniah, F., Aman Nasution, S., Ginanjar, E., Wicaksono Pitoyo, C., Susilo, A., Firdaus, I., Santoso, A., Arifa Juzar, D., Kamsul Arif, S., Lolong Wulung, N. G., Muchtar, F., Pulungan, A. B., Ambara Sjakti, H., Prawira, Y., Dwi Putri TIM PENYUSUN Erlina Burhan, N., Adityaningsih, D., Fahrial Syam, A., … Mayung Sambo, C. (2020). PEDOMAN TATALAKSANA COVID-19 Edisi 3 TIM EDITOR Perhimpunan Dokter Paru Indonesia (PDPI) Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (PERKI) Perhimpunan Dokter Spesialis Penyakit Dalam Indonesia (PAPDI) Perhimpunan Dokter Anestesiologi dan Terapi Intensif Indonesia (PERDATIN) Ikatan Dokter Anak Indonesia (IDAI).
Bwire, G. M. (2020a). Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women? SN Comprehensive Clinical Medicine, 2(7), 874–876. https://doi.org/10.1007/s42399-020-00341-w
Dalan, R. (2020). Metformin, neutrophils and COVID-19 infection. Diabetes Research and Clinical Practice, 164, 108230. https://doi.org/10.1016/j.diabres.2020.108230
Freeman, T. L., & Swartz, T. H. (2020). Targeting the NLRP3 Inflammasome in Severe COVID-19. In Frontiers in Immunology (Vol. 11). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2020.01518
Galani, I. E., & Andreakos, E. (2015). Neutrophils in viral infections: Current concepts and caveats. Journal of Leukocyte Biology, 98(4), 557–564. https://doi.org/10.1189/jlb.4VMR1114-555R
GarcÃa, L. F. (2020). Immune Response, Inflammation, and the Clinical Spectrum of COVID-19. In Frontiers in Immunology (Vol. 11). Frontiers Media S.A.
Gupta, S., & Kaplan, M. J. (2016). The role of neutrophils and NETosis in autoimmune and renal diseases. In Nature Reviews Nephrology (Vol. 12, Issue 7, pp. 402–413). Nature Publishing Group. https://doi.org/10.1038/nrneph.2016.71
Lucas, C., Wong, P., Klein, J., Castro, T. B. R., Silva, J., Sundaram, M., Ellingson, M. K., Mao, T., Oh, J. E., Israelow, B., Takahashi, T., Tokuyama, M., Lu, P., Venkataraman, A., Park, A., Mohanty, S., Wang, H., Wyllie, A. L., Vogels, C. B. F., … Iwasaki, A. (2020). Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature, 584(7821), 463–469. https://doi.org/10.1038/s41586-020-2588-y
Meizlish 2020a. (n.d.). Retrieved March 27, 2021, from https://covid-19.cochrane.org/studies/crs-16721378
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014). Reactive oxygen species in inflammation and tissue injury. In Antioxidants and Redox Signaling (Vol. 20, Issue 7, pp. 1126–1167). Mary Ann Liebert, Inc. https://doi.org/10.1089/ars.2012.5149
Parackova, Z., Zentsova, I., Bloomfield, M., Vrabcova, P., Smetanova, J., Klocperk, A., Mesežnikov, G., Casas Mendez, L. F., Vymazal, T., & Sediva, A. (2020). Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness. Cells, 9(10), 2206. https://doi.org/10.3390/cells9102206
Peta Sebaran COVID-19 | Covid19.go.id. (n.d.). Retrieved March 25, 2021, from https://covid19.go.id/peta-sebaran-covid19
Reusch, N., De Domenico, E., Bonaguro, L., Schulte-Schrepping, J., Baßler, K., Schultze, J. L., & Aschenbrenner, A. C. (2021). Neutrophils in COVID-19. In Frontiers in Immunology (Vol. 12). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2021.652470
Schauer, C., Janko, C., Munoz, L. E., Zhao, Y., Kienhöfer, D., Frey, B., Lell, M., Manger, B., Rech, J., Naschberger, E., Holmdahl, R., Krenn, V., Harrer, T., Jeremic, I., Bilyy, R., Schett, G., Hoffmann, M., & Herrmann, M. (2014). Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nature Medicine, 20(5), 511–517. https://doi.org/10.1038/nm.3547
Schönrich, G., & Raftery, M. J. (2016). Neutrophil extracellular traps go viral. In Frontiers in Immunology (Vol. 7, Issue SEP, p. 366). Frontiers Media S.A. https://doi.org/10.3389/fimmu.2016.00366
Vaninov, N. (2020). In the eye of the COVID-19 cytokine storm. Nature Reviews Immunology, 20(5), 277. https://doi.org/10.1038/s41577-020-0305-6
Ye, Q., Wang, B., & Mao, J. (2020). The pathogenesis and treatment of the ‘Cytokine Storm’’ in COVID-19.’ In Journal of Infection (Vol. 80, Issue 6, pp. 607–613). W.B. Saunders Ltd. https://doi.org/10.1016/j.jinf.2020.03.037
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